🧬✨ GDNF Gene Therapy for Parkinson’s ✨🧬 This is about AB-1005 (AAV2-GDNF), a cutting-edge gene therapy in Parkinson’s. ✅ Phase 1b started in 2020, wrapped up Oct 2023 ✅ 11 participants, infused directly into the putamen ✅ Safe well tolerated (no treatment-related serious adverse events over 18–36 months) ✅ Moderate PD: more “Good ON” time, less “OFF” time, reduced dyskinesia—even with lower meds ✅ Mild PD: clinically stable, no worsening ✅ Published in Movement Disorders (May 2025) This trial
1:44
🧬✨ GDNF Gene Therapy for Parkinson’s ✨🧬 This is about AB-1005 (AAV2-GDNF), a cutting-edge gene therapy in Parkinson’s. ✅ Phase 1b started in 2020, wrapped up Oct 2023 ✅ 11 participants, infused directly into the putamen ✅ Safe well tolerated (no treatment-related serious adverse events over 18–36 months) ✅ Moderate PD: more “Good ON” time, less “OFF” time, reduced dyskinesia—even with lower meds ✅ Mild PD: clinically stable, no worsening ✅ Published in Movement Disorders (May 2025) This trial
8.4K views9 months ago
FacebookReka Janisse
🧬✨ GDNF Gene Therapy: AB-1005 Moves Into Phase 2 REGENERATE-PD ✨🧬 The next chapter is here. Phase 2 is now enrolling for AB-1005 (AAV2-GDNF), a one-time gene therapy infusion targeting the putamen in Parkinson’s disease. ✅ Officially called REGENERATE-PD (NCT06285643) ✅ 2024–2027 study, across the U.S. and Europe ✅ Goal: ~75 participants with mild to moderate Parkinson’s ✅ Randomized, double-blind, placebo-controlled design ✅ Recruiting at top research centers like Duke, UCSF, Mount Sinai, and
2:22
🧬✨ GDNF Gene Therapy: AB-1005 Moves Into Phase 2 REGENERATE-PD ✨🧬 The next chapter is here. Phase 2 is now enrolling for AB-1005 (AAV2-GDNF), a one-time gene therapy infusion targeting the putamen in Parkinson’s disease. ✅ Officially called REGENERATE-PD (NCT06285643) ✅ 2024–2027 study, across the U.S. and Europe ✅ Goal: ~75 participants with mild to moderate Parkinson’s ✅ Randomized, double-blind, placebo-controlled design ✅ Recruiting at top research centers like Duke, UCSF, Mount Sinai, and
2.4K views9 months ago
FacebookReka Janisse
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