The Buffalo Bills (9-2) will try to build on a six-game winning streak when they host the San Francisco 49ers (5-6) on Sunday ...

In honor of World Aids Day, San Franciscans came together at the National AIDS Memorial Grove in San Francisco on Saturday ...

The 49ers look to turn around their season with a win in Buffalo against the Bills, who are chasing the top seed in the AFC.

San Francisco 49ers quarterback Brock Purdy is active for the team's Week 13 matchup versus the Buffalo Bills.

Buffalo Bills fans did their best to shovel out the field, seats and pathways ahead of the team's game against the San Francisco 49es amid a snowstorm.

The Buffalo Bills' first snow game of the season comes in an important showdown Sunday night against the San Francisco 49ers.

Rescuers pulled 18 people from the San Francisco Bay after a boat carrying a rowing team capsized, California officials ...

The 49ers take on the Bills on "Sunday Night Football" in Week 13. Here's the latest on if QB Brock Purdy will be available ...

Willy Adames is the top shortstop available this offseason, and Bleacher Report has named him a 'perfect fit' for San Francisco. The market for Adames will be robust, especially since he has ...

Watch out for the tables on "Sunday Night Football." The nightcap of Sunday's action will be in northern New York with the ...

The call for help comes as lake effect snow heads into the Buffalo area for Sunday night’s game against the San Francisco ...

The Buffalo Bills will host the San Francisco 49ers at Highmark Stadium in Orchard Park, New York, on Sunday, December 1, at ...