Running back is one position that won't land particularly high on a list of San Francisco 49ers needs in the 2025 NFL draft.

Christian McCaffrey suffered what turned out to be a season-ending knee injury in the San Francisco 49ers’ Week 13 loss to ...

San Francisco running back Isaac Guerendo was injured and carted off early during the 49ers ‘ season finale versus the ...

The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 ...

In the Arizona Cardinals’ 47-24 victory over the San Francisco 49ers, 23 players participated in at least one of the 76 ...

San Francisco 49ers rookie RB Isaac Guerendo suffered MCL and ankle sprains against the Arizona Cardinals, avoiding an ACL ...

GLENDALE -- San Francisco 49ers RB Isaac Guerendo was carted off the field in Week 18's matchup against the Arizona Cardinals. He has already been ruled out with a knee and ankle injury. On just the ...

While the Lions are preparing to make a deep run in the playoffs, the 49ers have lost their last two games and have dropped ...

The 49ers will not retain Nick Sorensen as their defensive coordinator following a 6-11 season in which the squad finished 29th in points allowed, NFL Network Insiders Ian Rapoport and Tom Pelissero ...

San Francisco 49ers running back Isaac Guerendo was forced to exit Sunday's game against the Arizona Cardinals during the ...

San Francisco 49ers Isaac Guerendo was carted off the field Sunday against the Arizona Cardinals. He suffered the injury ...

The Detroit Lions visit the San Francisco 49ers in an NFC title game rematch that features both teams going different ...