San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

Kyle Shanahan explains why 49ers rookie Isaac Guerendo is ready to be the starter with Christian McCaffrey and Jordan Mason ...

Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

McCaffrey should be fine long term, though it's hard to say whether he'd be able to play again this season if the 49ers made ...

The San Francisco 49ers on Wednesday continued adjusting to life without running backs Christian McCaffrey and Jordan Mason.

A spate of injuries has derailed the 49ers' Super Bowl hopes his season, but the bigger question is if their title window has ...

The Buffalo Bills stuck it to “the man” after their win over the San Francisco 49ers. The Bills (10-2) won in Week 13 over ...

When Kyle Shanahan became head coach of the San Francisco 49ers in 2017, the team was in the midst of a rebuilding phase.

Just when it seemed that San Francisco 49ers running back Christian McCaffrey was starting to find his rhythm, in a moment of ...

Head coach Kyle Shanahan reflected on the team's performance against the Bills, previewed the upcoming Week 14 matchup ...