The San Francisco 49ers can't catch a break.Running back Christian McCaffrey left Sunday's 35-10 loss to the Buffalo Bills in ...

Kyle Shanahan said McCaffrey is believed to have injured his posterior cruciate ligament, which connects the thigh bone to ...

Buffalo claimed the AFC East title for a franchise-record fifth straight season with a 35-10 victory over the San Francisco ...

Allen's final numbers: 13 of 17 passing for 148 yards and two touchdowns, three rushes for 18 yards and a score, and zero ...

Tony Dungy and Rodney Harrison explain to Jac Collinsworth how the Bills have built a defense that can stick with anybody, ...

RB Christian McCaffrey suffered a knee injury during Sunday night’s game against the Bills and has since been ruled out. ...

Fantasy football analyst Matt Harmon delivers his thoughts on the major happenings of Week 13's Sunday action.

Buffalo's Allen became the first quarterback in NFL history to run, pass and receive touchdowns in a single game.

The Buffalo Bills have secured their fifth straight AFC East title thanks to their Week 13 win over the San Francisco 49ers.

Buffalo Bills tight end Dawson Knox follows up a contested 17-yard grab by making snow angels on the field. San Francisco ...

San Francisco 49ers running back Christian McCaffrey is feared to have suffered a season-ending PCL injury vs. the Buffalo ...