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KRAS drug resistance has upstream cause: METTL13 enzyme fuels tumor protein overload

KRAS cancer treatment may have a new upstream target: the METTL13 enzyme that helps tumors overproduce KRAS protein and ...
BIOENGINEER

Scientists reveal how a methyl tag on eEF1A speeds KRAS translation and fuels cancer drug resistance

St. Jude scientists showed that METTL13-driven methylation of the translation factor eEF1A selectively speeds decoding of ...

A protein that regulates mRNA decoding can itself be regulated with implications for understanding cancer

Decoding of messenger RNA (mRNA) occurs during translation, the vital cellular process that builds proteins. Errors in this ...
BIOENGINEER

Methylated translation factor speeds decoding of rare codons to drive cancer growth

A methylation mark on translation factor eEF1A selectively speeds decoding of rare, wobble-weak codons, boosting KRAS ...