The Bills controlled the game on the ground as the snow played a significant role, with Buffalo finishing the game with 220 ...

McCaffrey left Sunday’s blowout loss in Buffalo with a knee injury, and Kyle Shanahan was quick to rule him out.

Facing their seventh loss of the season, 49ers HC Kyle Shanahan gave an update on RB Christian McCaffrey who left the game ...

San Francisco 49ers running back Christian McCaffrey's season might be over after he suffered a PCL injury on "Sunday Night ...

Officials in upstate New York counties have declared a state of emergency as they prepare for a major snowstorm that has ...

San Francisco 49ers head coach Kyle Shanahan revealed Sunday night that the team fears running back Christian McCaffrey ...

A picturesque setting of snow was the perfect backdrop for a Buffalo Bills team that has now won its fifth straight AFC East ...

The Buffalo Bills dominated the San Francisco 49ers on Sunday night, winning 35-10 in Highmark Stadium in Orchard Park, N.Y.

Buffalo's Allen became the first quarterback ever to score touchdowns running, passing and receiving in a single game.

Buffalo Bills quarterback Josh Allen's third quarter touchdown was his second passing touchdown - and first receiving ...

The Buffalo Bills host the San Francisco 49ers on Sunday Night Football in a week 13 clash.The Bills (9-2) are coming off six-straight wins while the Niners (5-6) have lost back-to-back games coming ...

The 49ers season is still trending down and now they're searching for answers on if they can get back on track.