Anti-amyloid immunotherapies come with a risk of serious brain hemorrhage, which can be mitigated via monitoring for amyloid-related imaging abnormalities (ARIA) via MRI scans. Early signs of edema ...

In the latest development on diagnostic methods for Alzheimer’s disease going mainstream, the U.S. Food and Drug Administration approved clinical use of Lantheus’ tau PET tracer florquinitau, aka ...

Two groups of scientists have found that the same protein can have opposing effects on α-synuclein pathology. Microglia eliminate α-synuclein from neurons by “trogocytosis.” Silencing the glycoprotein ...

How much do blood-based biomarkers help in diagnosing Alzheimer’s disease? Quite a lot, according to scientists led by Albert Puig Pijoan and Marc Suárez-Calvet at the Hospital del Mar in Barcelona, ...

The tau locus comes in two major genetic configurations, the H1 and H2 haplotypes. The latter carries a stretch of DNA, including the tau gene, that is flipped in orientation. As it turns out, a ...

Also the 24th Alzheimer's Disease and Related Disorders Annual convention of the Dementia Society of the Philippines ...

Ask a clinician or a researcher about the blood-brain barrier (BBB) in Alzheimer’s disease, and you may hear about amyloid or leaky tight junctions. Fibronectin, a major scaffold protein, won’t ...

Does menopausal hormone therapy raise or lower a woman’s risk of developing dementia? That is a burning question scientists and doctors are trying to answer 23 years after the Women’s Health ...

Shape-shifting cells may explain why APOE4 carriers are at greater risk of cerebrovascular disease. In the 24 September Cell, scientists led by Joel Blanchard at the Icahn School of Medicine at Mount ...

During ARIA, immune cells march from blood to brain. What sparks this mobilization? Scientists led by Moustafa Algamal, Mariel Kozberg, and Brian Bacskai at Mass General Brigham investigated this ...