How much do blood-based biomarkers help in diagnosing Alzheimer’s disease? Quite a lot, according to scientists led by Albert Puig Pijoan and Marc Suárez-Calvet at the Hospital del Mar in Barcelona, ...
When it comes to new brain anatomy, clearance pathways seem to be the gift that keeps on giving. In a preprint posted September 27 on bioRxiv, scientists led by David Attwell at University College ...
Another tau-lowering drug has shown it can hit its target in a Phase 1 trial. Arrowhead Pharmaceuticals, based in Pasadena, California, reported October 14 that its brain shuttle, tau-directed siRNA, ...
Two groups of scientists have found that the same protein can have opposing effects on α-synuclein pathology. Microglia eliminate α-synuclein from neurons by “trogocytosis.” Silencing the glycoprotein ...