It’s finally over. The San Francisco 49ers lost to the Arizona Cardinals on Sunday to put a stamp on what was one of the ...

San Francisco running back Isaac Guerendo was injured and carted off early during the 49ers’ season finale versus the Arizona ...

The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 ...

GLENDALE -- San Francisco 49ers RB Isaac Guerendo was carted off the field in Week 18's matchup against the Arizona Cardinals. He has already been ruled out with a knee and ankle injury. On just the ...

The NFL Week 17 schedule concludes with a pair of high-profile NFC teams on Monday Night Football. The Detroit Lions at San ...

The Niners face the team they took out in the NFC Championship in a role reversal with the Lions looking like a Super Bowl ...

While the Lions are preparing to make a deep run in the playoffs, the 49ers have lost their last two games and have dropped ...

The San Francisco 49ers today announced they have signed DL Tarron Jackson to the team's practice squad. Jackson (6-2, 254) was originally drafted by the Philadelphia Eagles in the sixth round (191st ...

Arizona State RB Cam Skattebo adds fuel to discussions linking him to San Francisco 49ers draft strategy amid backfield challenges.

The San Francisco 49ers announced a series of roster moves ahead of their Week 17 matchup, including activating LB Tatum ...

San Francisco 49ers running back Isaac Guerendo is expected to return from foot and hamstring injuries and play Monday, a ...

San Francisco 49ers running back Isaac Guerendo is set to return from foot and hamstring injuries and play Monday vs. the ...