It’s finally over. The San Francisco 49ers lost to the Arizona Cardinals on Sunday to put a stamp on what was one of the ...

San Francisco running back Isaac Guerendo was injured and carted off early during the 49ers’ season finale versus the Arizona ...

The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 ...

GLENDALE -- San Francisco 49ers RB Isaac Guerendo was carted off the field in Week 18's matchup against the Arizona Cardinals. He has already been ruled out with a knee and ankle injury. On just the ...

The NFL Week 17 schedule concludes with a pair of high-profile NFC teams on Monday Night Football. The Detroit Lions at San ...

The Niners face the team they took out in the NFC Championship in a role reversal with the Lions looking like a Super Bowl ...

San Francisco 49ers head coach Kyle Shanahan recapped the team's 47-24 loss to the Arizona Cardinals and evaluated the 49ers overall performance in Week 18.

San Francisco 49ers QB Joshua Dobbs and LB Fred Warner reacted to the 49ers season finale against the Arizona Cardinals.

San Francisco 49ers quarterback Brock Purdy suffered an elbow injury in the final minutes of the team’s 40-34 loss to the ...

Arizona State RB Cam Skattebo adds fuel to discussions linking him to San Francisco 49ers draft strategy amid backfield challenges.

James Conner will not play in the Arizona Cardinals ’ season finale against the San Francisco 49ers, coach Jonathan Gannon said Wednesday.

Arizona Cardinals running back James Conner has been ruled out of Sunday's game against the San Francisco 49ers due to a knee ...