The 49ers just lost 35-10 to the Buffalo Bills. Now the 49ers are 5-7 and all alone in last place in the NFL West. Here are ...

San Francisco coach Kyle Shanahan told reporters postgame that their star running back had injured the posterior cruciate ...

Josh Allen scored a receiving touchdown on a pass he threw in his latest do-everything performance, and the Buffalo Bills ...

If you didn't know the San Francisco 49ers were Super Bowl contenders last season, you might not believe it now. The 5–6 team ...

The Buffalo Bills dominated the San Francisco 49ers on Sunday night, winning 35-10 in Highmark Stadium in Orchard Park, N.Y.

Buffalo Bills fans are a different breed. They smash flaming tables, drink out of bowling balls, slide down makeshift snow ...

San Francisco 49ers running back Christian McCaffrey suffered another injury in just his fourth game of the season. During ...

Buffalo Bills star quarterback Josh Allen pulled off another mind-blowing touchdown that had the football world buzzing.

Kyle Shanahan said McCaffrey is believed to have injured his posterior cruciate ligament, which connects the thigh bone to ...

Somehow Week 13 was worse than for the San Francisco 49ers than Week 12. The 49ers fell behind 21-3 at halftime and had a ...

Christian McCaffrey is dealing with an injury again. The 49ers running back went down with a knee injury in the second ...