It's Buffalo Bills vs San Francisco 49ers in Week 13 of the NFL season. Can Josh Allen and company outduel Christian McCaffery and Deebo Samuel?

The Bills (10-2) ended up winning in a rout in a 35-10 final over the 49ers (5-7). That was just the start of it. On a ...

The Bills and the San Francisco 49ers went head-to-head in freezing conditions Sunday, with Bills fans and staff digging out ...

In Sunday's 35-10 win over the San Francisco 49ers, The Buffalo Bills used Alec Anderson as a third tackle on 17 plays, and ...

Buffalo Bills fans embraced the snowy conditions at Highmark Stadium in Orchard Park, New York, on December 1, as their team ...

The weather outside was frightful at Highmark Stadium in Orchard Park, New York on Sunday night, but the way the San ...

There's even a chance Guerendo, who pulled his hamstring on the first day of training camp and missed the first two preseason ...

The Great Lakes experienced a surge of activity as arctic air passed over record-warm waters, generating prolific snowfall.

RB Christian McCaffrey suffers potentially season-ending knee injury in loss to Bills, adding to team's struggles.

A Buffalo Bills fan tried to knock down Jake Moody's field goal attempt in the 49ers' snow-filled game tonight.

In a season that began with many questions and lowered expectations, it was apt watching Bills quarterback Josh Allen join ...

Back-to-back blowout losses and another injury to star back Christian McCaffrey might just be the final blow to the dwindling ...