Brock Purdy threw a career-high five touchdown passes and Dee Winters returned an interception 74 yards for a score to lead ...

Purdy torched the Colts with a career-high five touchdowns, etching his name in 49ers history and dominating Monday Night ...

Here is a closer look at the 49ers' injuries, how the team has been impacted in comparison to other NFL franchises and a year-by-year timeline of absences to key players.

Something Purdy had in common with 44-year-old Philip Rivers on Monday — mental sharpness, which came in handy in a big ...

Brock Purdy and the San Francisco 49ers spoiled Philip Rivers' return to Indianapolis, as they took down the Colts to remain ...

This was Purdy at his dart-throwing best, completing 25 of 34 passes for 295 yards and five touchdowns, the first time any ...

San Francisco 49ers head coach Kyle Shanahan had strong praise for quarterback Brock Purdy after Monday night's 48-27 win ...

The San Francisco 49ers beat the Indianapolis Colts 48-27 as Brock Purdy throws five TDs and reflects on facing Philip Rivers in his return.

San Francisco 49ers quarterback Brock Purdy was named NFC Offensive Player of the Week after the team's Week 16 win over the ...