Gut

Kupffer cell autophagy emerges as a central regulator of immune dysregulation in primary biliary cholangitis

Primary biliary cholangitis (PBC) is a rare chronic autoimmune cholangiopathy that mainly affects middle-aged women, ...
Gut

Real-world evidence supports earlier treatment in HBeAg-positive but not HBeAg-negative chronic hepatitis B virus infection

In chronic hepatitis B virus (HBV) infection, the central debate remains whom and when to treat. The 2025 European Association for the Study of the Liver (EASL) Clinical Practice Guidelines (CPGs)1 ...
Gut

Post-infection disorders of gut-brain interaction: results of the Rome Foundation Global Epidemiology Study

Background Post-infection disorders of gut-brain interaction (PI-DGBI) are a subset of chronic gastrointestinal disorders triggered by acute infectious gastroenteritis. These conditions impose a ...
gut.bmj

Recent advances in clinical practice: epidemiology of autoimmune liver diseases

2 Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK 3 Institute of Applied Health Research, University of Birmingham, Birmingham, UK Correspondence to Dr Palak J ...
gut.bmj

The HLF/IL-6/STAT3 feedforward circuit drives hepatic stellate cell activation to promote liver fibrosis

Correspondence to Hong-Yang Wang and Jin Ding, The International Cooperation Laboratory on Signal Transduction, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 ...
gut.bmj

Antiviral therapy for chronic hepatitis delta: new insights from clinical trials and real-life studies

Chronic hepatitis D (CHD) is the most severe form of viral hepatitis, carrying a greater risk of developing cirrhosis and its complications. For decades, pegylated interferon alpha (PegIFN-α) has ...
gut.bmj

Microbial determinants of effective donors in faecal microbiota transplantation for UC

Objective Faecal microbiota transplantation (FMT) has variable efficacy in treating UC. Recently, oral lyophilised FMT was found to induce remission in patients with UC, with one donor having 100% ...
gut.bmj

Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis

Objective Acinar cells display plasticity in vitro and in vivo and can activate a variety of differentiation programmes that may contribute to pancreatic diseases. The aims were to determine: (1) the ...
gut.bmj

Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn’s disease

Objective Intestinal barrier loss is a Crohn’s disease (CD) risk factor. This may be related to increased expression and enzymatic activation of myosin light chain kinase 1 (MLCK1), which increases ...
gut.bmj

A signalling cascade of IL-33 to IL-13 regulates metaplasia in the mouse stomach

Correspondence to Dr James R Goldenring, Epithelial Biology Center and Section of Surgical Sciences, Vanderbilt University Medical Center, 10435-G MRB IV, 2213 Garland Avenue, Nashville, TN 37232, USA ...
gut.bmj

IDDF2025-ABS-0191 Development of 3D multi-scale vascularized sinusoid-like model for liver tissue repair bridging for liver transplant

Background Liver failure is the most critical outcome of end-stage liver diseases, with a 28-day mortality rate in the acute phase ranging from 25% to 84% due to a narrow therapeutic window. Liver ...
gut.bmj

Multivalent tyrosine kinase inhibition promotes T cell recruitment to immune-desert gastric cancers by restricting epithelial-mesenchymal transition via tumour-intrinsic IFN-γ ...

Objective Gastric cancer (GC) ranks fifth in incidence and fourth for mortality worldwide. The response to immune checkpoint blockade (ICB) therapy in GC is heterogeneous due to tumour-intrinsic and ...