AbstractBackground:. Cancer-related cognitive difficulties (CRCD) is a common and distressing condition with limited effective treatments. This study aims to evaluate the effects of acupuncture on ...

NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale—within the United States—of Bavencio (avelumab), a ...

Abstract. The overexpression of HER3 in solid tumors is associated with poor prognosis. Therapies developed to target HER3-mediated signaling are often associated with resistance over time, ...

AbstractBackground:. Urothelial carcinoma (UC) affects over 600,000 patients worldwide annually, with the incidence rate increasing over the past decade. Metastatic urothelial carcinoma (mUC) has a ...

Abstract. Regulatory T cells (Tregs) have long been appreciated as a key suppressive cell type that limits anti-tumor immunity, yet it has been challenging to find an effective approach to target this ...

Abstract. EGFR-TKIs like osimertinib are widely used to treat advanced EGFR-mutant NSCLC, however tumors inevitably acquire resistance. Amplification of MET occurs in ~20% of EGFR-TKI resistant tumors ...

From molecules to medicine, from proteomics to prevention, the journals of the AACR cover the entire spectrum of cancer research. Please select the journal that is most appropriate for your manuscript ...

1Center for Immune-Related Diseases at Shanghai Institute of Immunology, State Key Laboratory of Systems Medicine for Cancer, Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong ...

Ming Li Han Liang Jonathan Licht De-Chen Lin Hui-Kuan Lin Piro Lito David Lyden Conor C. Lynch Mathieu Lupien Li Ma Anant Madabhushi Andriy Marusyk Massimiliano Mazzone John D. Minna Lindsay M. Morton ...

Developing drugs against multi-protein complexes is traditionally challenging. In this study, we develop molecular COUPLrs, dual cysteine-reactive small molecules, that can engage complexes across the ...