Primary bile acids are synthesized from cholesterol in the liver, which is transformed to cholic acid (CA) through the classical pathway and chenodeoxycholic acid (CDCA) as an alternative pathway.

Bile has a bad rap and often connotes an ill temper. But it plays a critical role in digestion and, thanks to new work, might eventually reduce the need for needles. While most people prefer oral ...

Bile acids are essential to digestion, by acting like a kind of detergent that breaks up fat molecules. Fat doesn't dissolve in water, but our digestive system is full of water, so the fat we consume ...

Background Western diet and associated production of secondary bile acids (BAs) have been linked to the development of ...

Immunotherapy is a modern approach to cancer treatment that uses a patient's own immune system to help fight tumors. It has made an incredible impact on treating cancers in many different organ ...

Scientists have discovered a new role for bile acids: they curb appetite by entering the brain. Their findings provide new insights into the signals and mechanisms by which satiety is controlled and ...

In a major step towards a precision therapy for Clostridioides difficile (C. diff) infection, researchers at The Hospital for ...

Bile acids that aid fat digestion are also found to reduce the rewarding properties of cocaine use, according to a new study. Bile acids that aid fat digestion are also found to reduce the rewarding ...

Mirum Pharmaceuticals’ MIRM revenue base is largely supported by its lead product, Livmarli (maralixibat), which has been ...