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Mastering bias-free epidemiology study designs

Observational study designs like cohort, case-control, and cross-sectional are the backbone of epidemiology, but each comes with unique strengths, limitations, and bias risks. Understanding these ...
Nature

Active-comparator design and new-user design in observational studies

Over the past decade, an increasing number of observational studies have examined the effectiveness or safety of treatments for rheumatoid arthritis. Unlike randomized controlled trials (RCTs), ...
Forbes

Jay Bhattacharya Called Test-Negative Study Design ‘Crap.’ Here’s How We Know Whether Vaccines Measured With It Are Effective

WASHINGTON, DC - MARCH 5: Jayanta Bhattacharya, U.S. President Donald Trump's nominee to be Director of the National Institutes of Health, speaks at his confirmation hearing before the Senate ...
The New England Journal of Medicine

Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both

High-quality evidence is what we use to guide medical practice. The standard approach to generating this evidence — a series of clinical trials, each investigating one or two interventions in a single ...