Proteins need to fold into specific shapes to perform their functions in cells, but they occasionally misfold, which can ...
An error in protein conformation can lead to disease. What are the genetic and molecular causes for incorrectly formed proteins? molecules. In 1917 the German chemist ...
When proteins are made in a cell, they start out as strings of amino acids, which have to be folded into the correct, three-dimensional shape so they will function properly. Misfolded proteins can ...
Prion diseases, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis (ALS) are all part of the landscape of neurodegenerative diseases linked to protein ...
AMES, Iowa – A new screening technique outlined in recently published research from biomedical scientists at Iowa State University could slash the time required to conduct experiments on prion ...
New computer simulations that model every atom of a protein as it folds into its final three-dimensional form support the existence of a recently identified type of protein misfolding. Proteins must ...
"Science is teamwork. Lone wolves no longer exist," Peter Walter, researcher and professor at the University of California, San Francisco, and former president of the American Society for Biochemistry ...
Recently identified and long-lasting type of protein misfolding — non-native entanglements — observed in all-atom protein folding simulations. Representative misfolded conformations of the small ...
The brain of a rat in which a fluorescent protein has been used to highlight transplanted human brain cells - Copyright Stanford University/AFP Sergiu PASCA The brain ...
Researchers have identified a new function of a well-known enzyme: the signal peptidase complex is responsible for the quality control of membrane proteins. The discovery of this new function for a ...
When proteins misfold, accumulate and clump around insulin-producing cells in the pancreas, they kill cells. Now, researchers, including University of Michigan biophysicists, have obtained a ...
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