Exon junction complexes are deposited at exon-exon junctions during splicing. They are primarily known to activate non-sense mediated degradation of transcripts harbouring premature stop codons before ...
The vast majority of mammalian cell pre-mRNAs contain multiple introns that must be removed before the resulting mRNA, which consists only of exons, can produce the encoded protein having the ...
A post-splicing complex deposited upstream of each exon-exon junction tags mRNAs for nuclear export and mRNA surveillance. The pre-mRNA is coated with hnRNP proteins. The Spliceosome deposits an ...