Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment has been the focus of a 30-year research question. New work from the Crick ...

DNA replication and repair mechanisms constitute the foundation of genomic integrity, ensuring that genetic information is faithfully duplicated and maintained across cell generations. Replication ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

Before a cell can divide, it has to precisely duplicate its entire genetic information. However, the DNA in the cell exists as part of a DNA-protein complex known as chromatin. For this purpose, the ...

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...

In simple terms: a virus is a tiny package of genetic instructions with a delivery system. Outside a cell it is metabolically inert. Once inside a susceptible cell, it redirects the cell's machinery ...

DNA can be more than just a double helix. When four strands are folded into a compact bundle, they form a G-quadruplex (G4). These bundles form in guanine-rich regions across the genome, including ...

In the middle of the 20th century, accumulating data suggested that DNA carries life’s genetic information. Biochemists around the world raced to determine its structure. The competition led to some ...