Diffuse intrinsic pontine glioma (DIPG) is one of the most devastating pediatric brain tumors. It sits in the brainstem where it cannot be surgically removed, responds poorly to chemotherapy, and ...

Cellares and City of Hope announced a collaboration Jan. 8 to evaluate automated manufacturing for an investigational CAR T cell therapy. The effort will target glioblastoma multiforme, a fast-growing ...

Chimeric antigen receptor (CAR) T cell therapy, which uses a patient's own immune cells to fight cancer, has emerged as a powerful way to treat lymphoma and other blood cancers. But researchers have ...

Chimeric antigen receptor T-cell therapy (CAR T) has revolutionized oncology treatment over the last decade, offering targeted therapy options for several difficult cancers, espec ...

Scientists at the Icahn School of Medicine at Mount Sinai have developed an experimental immunotherapy that takes an unconventional approach to metastatic cancer. Rather than targeting cancer cells ...

Glioblastoma multiforme cells, illustration. Glioblastoma multiforme is a malignant tumor that arises from astrocytes, one of the support cells of the brain. It is an aggressive cancer with a poor ...

A new clinical trial is enrolling up to 60 children and young people with solid tumors across the United States and United ...

UCLA scientists have developed a next-generation CAR-T cell therapy that can overcome the immunosuppressive tumor microenvironment, a protective shield that tumors use to weaken immune cells, block ...

Please provide your email address to receive an email when new articles are posted on . Multiple CAR T-cell therapy strategies have exhibited clinical activity in recurrent glioblastoma. Early data ...

Normally, CAR T cells are designed to recognize and kill cancer cells, but for many types of cancers there are not good ways to make the CAR T cells do that. Therefore, the team designed the CAR T ...

Among the most promising tools of cancer therapy, engineered immune cells known as chimeric antigen-receptor (CAR) T cells have already transformed the treatment of blood cancers. Yet, despite their ...