A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential ...

Discovery reshapes understanding of how tumor cells repair broken DNA, pointing toward more precise cancer therapies.

Conceptual illustration showing how high transcriptional activity driven by super-enhancers can lead to DNA breaks at oncogenes. When these breaks are repaired inaccurately, they can give rise to ...

Drs Ursula A. Matulonis and Joyce F. Liu discuss targeting DNA damage and repair and replication stress in endometrial cancer. Drs Ursula A. Matulonis and Panagiotis A. Konstantinopoulos discuss ...

A new hereditary condition has been discovered that affects patients' ability to repair DNA – leaving them both at greater risk of developing blood cancer, and unable to repair some of the damage ...

Researchers have uncovered an early survival response in ovarian cancer cells that may limit the effectiveness of widely used PARP inhibitors.

A new pan-cancer study has uncovered a shared vulnerability across multiple aggressive cancers and sheds light on the role ...

A new fluorescent sensor is giving scientists an unprecedented view of how cells respond to DNA damage, capturing the repair process as it unfolds in real time. The tool, developed at Utrecht ...

Colorectal cancer, long associated with aging, is rising alarmingly in younger adults, especially those born in the 1980s. Investigators are looking past family history and lifestyle to mutational ...

The bowhead whale is one of nature’s most remarkable survivors. Living for more than two centuries and weighing over 80,000 kilograms, it challenges one of biology’s most persistent questions: why do ...