Results reported in the Journal of Clinical Investigation have identified Vad1, a DEAD-box RNA helicase, as a putative global virulence regulator in Cryptococcus neoformans. The authors used a random ...

Autophagy is a process whereby cells recycle material during stress situations, such as when nutrients are scarce. Some cells also use this process as an immune defense mechanism to eliminate ...

The two studies are reported by Joseph Heitman and colleagues at Duke University Medical Center and by Fritz Mühlschlegel of the University of Kent, Jochen Buck at Cornell University, and their ...

C. neoformans is a fungal pathogen that causes meningitis, which causes approximately 180,000 deaths annually worldwide. Currently, AmB is the only fungicidal drug available to treat fungal meningitis ...

A pathogen's ability to infect or damage its host tissues is determined by the virulence factors. These are often molecules synthesized by bacteria or viruses and encoded in their genome, but they may ...

3 Graduate Program in Immunology, University of Michigan Medical School, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA 4 Department of Microbiology & Immunology, University of Michigan ...