Triple Intrathecal Therapy Alone With Omission of Cranial Radiation in Children With Acute Lymphoblastic Leukemia Discovery of Bruton's tyrosine kinase (BTK) mutations as the cause for X-linked ...

X-linked agammaglobulinemia (XLA), caused by mutations in Bruton's tyrosine kinase (BTK), is the most common form of inherited antibody deficiency (Conley 1992). While pro-B cells in the bone marrow ...

Extract: Peripheral blood leukocytes from eleven normal individuals and five boys with Bruton-type agammaglobulinemia were cultured in vitro with Candida albicans antigen. The lymphocyte response in ...

Tyrosine kinases, a ubiquitous and diverse family of enzymes, are of considerable clinical interest because they directly contribute to the development of cancer. A growing number of tyrosine kinase ...

The patient described below is of interest because she represents one of the first cases that have been followed since the inception of the disease. Since that time many of the complications mentioned ...

Agammaglobulinemia is a set of inherited immunological disorders marked by low antibody levels in the blood due to a lack of certain lymphocytes in the blood and lymph. Agammaglobulinemia is a set of ...