The findings suggest recombinant ADAMTS-13 may be a useful adjunct therapy to plasma exchange among patients who have thrombotic thrombocytopenic purpura (iTTP). Clearance of ADAMTS-13 mediated by ...

There is the Addams Family. And then there is the ADAMTS family. While one is mindless entertainment, the latter may prove to be a new genetic avenue for designing ovarian cancer treatment, scientists ...

Thrombotic microangiopathies are characterized by thrombocytopenia (with increased numbers of marrow megakaryocytes), fragmentation of erythrocytes, and extremely elevated serum levels of lactate ...

ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) proteases constitute a family of secreted zinc-dependent enzymes that orchestrate the remodelling of the cartilage extracellular ...

Loss of articular cartilage caused by extracellular matrix breakdown is the hallmark of arthritis. Degradative fragments of cartilage oligomeric matrix protein (COMP) have been observed in arthritic ...