UofL was placed in the South Region, and their first and second round games will be played at Rupp Arena in Lexington, Ky. They're matched up against No. 1 Auburn vs. No. 16 Alabama State/St. Francis, with the top four teams in the region being Auburn, Iowa State, Michigan State and Texas A&M.

It’s Louisville Cardinals vs Creighton Bluejays to begin March Madness. Here’s our prediction for the 2025 NCAA Tournament basketball game.

What began with 15 teams has dwindled to two in Charlotte, North Carolina, as the ACC Tournament bracket has chewed up and spit out 13 others to leave us with No. 1 seed Duke and No. 2 Louisville with only Saturday's title game remaining.